Concentrations of Gaseous Transmitters during Catecholamine Damage to the Myocardium in Rats


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Abstract

Gaseous transmitters were assayed in rat blood during catecholamine-induced damage to the heart. Hypercatecholaminemia was modeled by single subcutaneous injection of 0.1% epinephrine hydrochloride in a dose of 2 mg/kg. The blood concentrations of NO, H2S, and CO were measured. The catecholamine-induced damage to the myocardium resulted in phasic changes in the blood levels of gaseous transmitters: CO concentration increased in 1 h, H2S increased in 24 h, and NO concentration increased in 72 h after injection.

About the authors

A. S. Ivanova

Ivanovo State Medical Academy, Ministry of Health of the Russian Federation

Author for correspondence.
Email: asivanova@mail.ru
Russian Federation, Ivanovo

O. G. Sitnikova

V. N. Gorodkov Ivanovo Research Institute of Maternal and Child Health Care, Ministry of Health of the Russian Federation

Email: asivanova@mail.ru
Russian Federation, Ivanovo

I. G. Popova

V. N. Gorodkov Ivanovo Research Institute of Maternal and Child Health Care, Ministry of Health of the Russian Federation

Email: asivanova@mail.ru
Russian Federation, Ivanovo

S. B. Nazarov

Ivanovo State Medical Academy, Ministry of Health of the Russian Federation; V. N. Gorodkov Ivanovo Research Institute of Maternal and Child Health Care, Ministry of Health of the Russian Federation

Email: asivanova@mail.ru
Russian Federation, Ivanovo; Ivanovo


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