Email this article Analysis of the Association of TNF -238G>A Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia
- Authors: Malysheva I.E.1, Topchieva L.V.1, Balan O.V.1, Marusenko I.M.2, Barysheva O.Y.2, Kurbatova I.V.1
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Affiliations:
- Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences
- Department of Hospital Therapy, Petrozavodsk State University
- Issue: Vol 165, No 5 (2018)
- Pages: 674-677
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240653
- DOI: https://doi.org/10.1007/s10517-018-4239-y
- ID: 240653
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Abstract
We studied association of the TNF gene -238G>A polymorphism (rs361525) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this disease is associated with the presence of GG genotype. The effect of the genotype on the polymorphic locus of -238G>A on TNF mRNA content was revealed. Increased content of transcripts of this gene is associated with the presence of A allele.
About the authors
I. E. Malysheva
Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences
Author for correspondence.
Email: ie.malysheva@yandex.ru
Russian Federation, Petrozavodsk, Republic of Karelia
L. V. Topchieva
Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences
Email: ie.malysheva@yandex.ru
Russian Federation, Petrozavodsk, Republic of Karelia
O. V. Balan
Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences
Email: ie.malysheva@yandex.ru
Russian Federation, Petrozavodsk, Republic of Karelia
I. M. Marusenko
Department of Hospital Therapy, Petrozavodsk State University
Email: ie.malysheva@yandex.ru
Russian Federation, Petrozavodsk, Republic of Karelia
O. Yu. Barysheva
Department of Hospital Therapy, Petrozavodsk State University
Email: ie.malysheva@yandex.ru
Russian Federation, Petrozavodsk, Republic of Karelia
I. V. Kurbatova
Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences
Email: ie.malysheva@yandex.ru
Russian Federation, Petrozavodsk, Republic of Karelia
