Email this article Anti-Ischemic Activity of n-Tyrozol under Conditions of Repeated Transient Myocardial Ischemia in Rats
- Authors: Plotnikov M.B.1, Chernysheva G.A.1, Smol’yakova V.I.1, Plotnikova T.M.2, Sysolyatin S.V.3, Kryukov Y.A.3
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
- Siberian State Medical University, Ministry of Health of Russia
- Institute for Problems of Chemical and Energetic Technologies, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 165, No 5 (2018)
- Pages: 625-628
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240609
- DOI: https://doi.org/10.1007/s10517-018-4228-1
- ID: 240609
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Abstract
We studied anti-ischemic activity of n-tyrozol under conditions of repeated transient myocardial ischemia in rats caused by repeated (5×3 min) occlusion of the left coronary artery. n-Tyrozol administered intraperitoneally in a dose of 20 mg/kg daily over 4 days before the ischemia modeling (the last injection 15 min prior to the start of the experiment) produced a clear-cut anti-ischemic effect: it reduced ST elevation and promoted more complete recovery of ECG during reperfusion. During reperfusion periods, n-tyrozol significantly decreased the risk of ventricular fibrillation and shortened the duration of tachyarrhythmia episodes (ventricular tachycardia and fibrillation).
About the authors
M. B. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Author for correspondence.
Email: mbp2001@mail.ru
Russian Federation, Tomsk
G. A. Chernysheva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: mbp2001@mail.ru
Russian Federation, Tomsk
V. I. Smol’yakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: mbp2001@mail.ru
Russian Federation, Tomsk
T. M. Plotnikova
Siberian State Medical University, Ministry of Health of Russia
Email: mbp2001@mail.ru
Russian Federation, Tomsk
S. V. Sysolyatin
Institute for Problems of Chemical and Energetic Technologies, Siberian Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Biysk
Y. A. Kryukov
Institute for Problems of Chemical and Energetic Technologies, Siberian Division of the Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, Biysk
