Neovascularization of Carotid Atherosclerotic Plaque and Quantitative Methods of Its Dynamic Assessment in Vivo
- Authors: Evdokimenko A.N.1, Gulevskaya T.S.1, Druina L.D.1, Chechetkin A.O.1, Shabalina A.A.1, Kostyreva M.V.1, Kulichenkova K.N.1, Pryamikov A.D.2, Tanashyan M.M.1
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Affiliations:
- Research Center of Neurology
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
- Issue: Vol 165, No 4 (2018)
- Pages: 521-525
- Section: Methods
- URL: https://journals.rcsi.science/0007-4888/article/view/240485
- DOI: https://doi.org/10.1007/s10517-018-4208-5
- ID: 240485
Cite item
Abstract
The study demonstrates significant variety of neovascularization degree and vessel diameter in the carotid atherosclerotic plaque. It is suggested that the increase in the number of vessels with a diameter <20 μ can be indicative of increased atherosclerosis activity, while the increase in the number of vessels with a diameter ≥40 μ indicates “reparative potential” of plaques. Duplex contrast-enhanced ultrasound scanning allows characterization of the localization and number of vessels with a diameter of ≥30 μ in the plaque, while even slight elevation of plasma concentration of basic fibroblast growth factor attests, first of all, to increased content of small vessels <30 μ in the plaque. The level of fibroblast growth factor >1.5 pg/ml is a reliable marker of increased number of both small and large vessels in the plaque.
About the authors
A. N. Evdokimenko
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
T. S. Gulevskaya
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
L. D. Druina
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
A. O. Chechetkin
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
A. A. Shabalina
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
M. V. Kostyreva
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
K. N. Kulichenkova
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
A. D. Pryamikov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow
M. M. Tanashyan
Research Center of Neurology
Email: bbm.ktbm@gmail.com
Russian Federation, Moscow