Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes

N. V. Yaglova; S. S. Obernikhin; D. A. Tsomartova; S. V. Nazimova; V. V. Yaglov

doi:10.1007/s10517-018-4205-8

Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes

Authors: Yaglova N.V.¹, Obernikhin S.S.¹, Tsomartova D.A.¹, Nazimova S.V.¹, Yaglov V.V.¹
Affiliations:
1. Research Institute of Human Morphology
Issue: Vol 165, No 4 (2018)
Pages: 508-511
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240465
DOI: https://doi.org/10.1007/s10517-018-4205-8
ID: 240465

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Abstract

Transcription factor PRH/Hhex suppresses cell proliferation and contributes to regulation of prenatal and postnatal ontogeny. Neurons of the peripheral nervous system and chromaffin cells were previously considered as non-expressing PRH/Hhex in postnatal development. In our study, the expression of PRH/Hhex in chromaffin cells of rat adrenal glands and association between the decrease of proliferation and activation of PRH/Hhex expression were demonstrated.