Experimental Application of Organic-Inorganic Hybrid Coatings with Adsorbed Bacteriophages for Reducing the Risk of STEC Infections
- Authors: Aleshkin A.V.1, Zulkarneev E.R.1, Kiseleva I.A.1, Emelyanenko K.A.2, Emelyanenko A.M.2, Boinovich L.B.1
-
Affiliations:
- G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology
- A. N. Frumkin Institute of Physical Chemistry and Electrochemistry
- Issue: Vol 165, No 4 (2018)
- Pages: 478-481
- Section: Immunology and Microbiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240436
- DOI: https://doi.org/10.1007/s10517-018-4198-3
- ID: 240436
Cite item
Abstract
A new approach to prevention of STEC infection is based on the synergic effect of combined bactericidal activity of bacteriophages and organic-inorganic hybrid coating of metals. The coatings are characterized by superhydrophilic or superhydrophobic properties and multimodal granularity with the texture incorporating metal oxide nanoparticles and bacteriophages. Superhydrophilic surfaces are characterized by significantly higher bactericidal activity than superhydrophobic ones. The cytotoxicity of superhydrophobic surfaces can be increased due to antibacterial activity of bacteriophages combined with the superhydrophobic characteristics of the materials.
About the authors
A. V. Aleshkin
G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology
Author for correspondence.
Email: andreialeshkin@gmail.com
Russian Federation, Moscow
E. R. Zulkarneev
G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology
Email: andreialeshkin@gmail.com
Russian Federation, Moscow
I. A. Kiseleva
G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology
Email: andreialeshkin@gmail.com
Russian Federation, Moscow
K. A. Emelyanenko
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: andreialeshkin@gmail.com
Russian Federation, Moscow
A. M. Emelyanenko
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry
Email: andreialeshkin@gmail.com
Russian Federation, Moscow
L. B. Boinovich
G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology
Email: andreialeshkin@gmail.com
Russian Federation, Moscow
![](/img/style/loading.gif)