Collagen Hydrolysis Products Reduce the Formation of Stress-Induced Ulcers by Regulating Stress-Associated Activation of the Neuroendocrine and Immune Systems
- Authors: Bakaeva Z.V.1,2, Ermakova N.V.1, Mankaeva O.V.1, Sveshnikov D.S.1, Severin A.E.1, Sinel’nikova A.N.1, Starshinov Y.P.1, Radysh I.V.1, Torshin V.I.1, Frolov D.A.1, Kozlov I.G.3
-
Affiliations:
- Peoples Friendship University of Russia
- National Medical Research Center of Children’s Health, Ministry of Health of the Russian Federation
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
- Issue: Vol 165, No 4 (2018)
- Pages: 449-452
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240403
- DOI: https://doi.org/10.1007/s10517-018-4191-x
- ID: 240403
Cite item
Abstract
We studied the effect of collagen fragments (PGP and AcPGP) on serum content of epinephrine, corticosterone, and IL-1β in rats subjected to water-immersion stress. The degree of local inflammation accompanying ulceration was assessed by IL-1β production by ln. gastricus caudalis cells. In 1 h, the sharp increase in hormone concentrations in the blood of stressed animals reflected the high stress intensity. Intranasal administration of PGP reduced the area of stress-induced ulcers by 63%, prevented the increase in the levels of stress hormones and the main proinflammatory cytokine in rat blood. The concentrations of IL-1β in cell culture from regional lymph node of experimental animals returned to normal in 24 and 48 h after the stress. Acetylation of PGP prevents with gastroprotection, but does not abrogate other properties of the peptide.
About the authors
Z. V. Bakaeva
Peoples Friendship University of Russia; National Medical Research Center of Children’s Health, Ministry of Health of the Russian Federation
Author for correspondence.
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow; Moscow
N. V. Ermakova
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
O. V. Mankaeva
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
D. S. Sveshnikov
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
A. E. Severin
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
A. N. Sinel’nikova
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
Yu. P. Starshinov
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
I. V. Radysh
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
V. I. Torshin
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
D. A. Frolov
Peoples Friendship University of Russia
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
I. G. Kozlov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology
Email: zv.bakaeva@gmail.com
Russian Federation, Moscow
![](/img/style/loading.gif)