Combined Effect of NF-κB Inhibitor and β2-Adrenoreceptor Agonist on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis
- Authors: Zabrodskii P.F.1, Gromov M.S.1, Maslyakov V.V.1
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Affiliations:
- Saratov Medical University REAVIZ
- Issue: Vol 165, No 4 (2018)
- Pages: 445-448
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240399
- DOI: https://doi.org/10.1007/s10517-018-4190-y
- ID: 240399
Cite item
Abstract
Experiments on random-bred albino mice showed that NF-κB inhibitor (BAY 11-7082) and β2-adrenoreceptor agonist (dexmedetomidine hydrochloride) significantly reduced mouse mortality in 4 and 24 h after sepsis modeling (intraperitoneal administration of E. coli) by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, and IL-6. The combined administration of NF-κB inhibitor and β2-adrenoreceptors agonist have an additive effect.
About the authors
P. F. Zabrodskii
Saratov Medical University REAVIZ
Author for correspondence.
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
M. S. Gromov
Saratov Medical University REAVIZ
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
V. V. Maslyakov
Saratov Medical University REAVIZ
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
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