Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications

G. V. Khlestova; A. Yu. Romanov; N. V. Nizyaeva; A. O. Karapetyan; O. R. Baev; T. Yu. Ivanets

doi:10.1007/s10517-018-4188-5

Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications

Authors: Khlestova G.V.¹, Romanov A.Y.¹, Nizyaeva N.V.¹, Karapetyan A.O.¹, Baev O.R.¹^,2, Ivanets T.Y.¹
Affiliations:
1. V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
2. Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Faculty of Postgraduate Professional Education, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Issue: Vol 165, No 4 (2018)
Pages: 438-439
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240393
DOI: https://doi.org/10.1007/s10517-018-4188-5
ID: 240393

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Abstract

Changes in the levels of rennin, angiotensin II, and angiotensin (1–7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentration were observed during normal pregnancy (p=0.423). The level of angiotensin II increased during normal pregnancy from 9.7±1.2 to 14.7±1.9 pg/ml (p=0.019). On the contrary, angiotensin (1–7) concentration decreased from 771.1±44.2 to 390.7±13.9 pg/ml (p<0.001). The shift in the proportion between vasoconstrictor angiotensin II and vasodilaltor angiotensin (1–7) attests to high predisposition of pregnant women to hypertension-related complications.