Email this article Effect of Water-Soluble Echinochrome Analog on Arrhythmia Severity in Experimental Model of Acute Myocardial Ischemia
- Authors: Bernikova O.G.1,2, Sedova K.A.1,3, Kharin S.N.1,4, Azarov Y.E.1,4
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Affiliations:
- Institute of Physiology, Komi Science Center, Ural Division of Russian Academy of Sciences
- Department of Therapy, Medical Institute of Pitirim Sorokin Syktyvkar State University
- Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University
- Department of Physiology, Medical Institute of Pitirim Sorokin Syktyvkar State University
- Issue: Vol 165, No 3 (2018)
- Pages: 340-343
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240281
- DOI: https://doi.org/10.1007/s10517-018-4165-z
- ID: 240281
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Abstract
The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.
About the authors
O. G. Bernikova
Institute of Physiology, Komi Science Center, Ural Division of Russian Academy of Sciences; Department of Therapy, Medical Institute of Pitirim Sorokin Syktyvkar State University
Author for correspondence.
Email: bernikovaog@gmail.com
Russian Federation, Syktyvkar; Syktyvkar
K. A. Sedova
Institute of Physiology, Komi Science Center, Ural Division of Russian Academy of Sciences; Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University
Email: bernikovaog@gmail.com
Russian Federation, Syktyvkar; Prague
S. N. Kharin
Institute of Physiology, Komi Science Center, Ural Division of Russian Academy of Sciences; Department of Physiology, Medical Institute of Pitirim Sorokin Syktyvkar State University
Email: bernikovaog@gmail.com
Russian Federation, Syktyvkar; Syktyvkar
Ya. E. Azarov
Institute of Physiology, Komi Science Center, Ural Division of Russian Academy of Sciences; Department of Physiology, Medical Institute of Pitirim Sorokin Syktyvkar State University
Email: bernikovaog@gmail.com
Russian Federation, Syktyvkar; Syktyvkar
