Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders


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Abstract

We studied the dynamics of respiratory function in rats during intratracheal poisoning with diisopropyl fluorophosphate and pentylenetetrazole in doses corresponding to the LD50 in humans. The maximum of external respiration impairment was recorded in 30 min after poisoning. Administration of diazepam and atropine both separately and in combination during the development of the first signs of poisoning did not significantly affect the respiration parameters, but reduced the incidence of seizures and contributed to a decrease in the rate of animal death. Intratracheal administration of cholinolytic, β2-adrenomimetic, or glutamate receptors antagonist promoted correction of the respiratory function. It was found that the maximum therapeutic effect in case of diisopropyl fluorophosphates poisoning was achieved after intratracheal administration of ipratropium bromide (0.086 mg/kg), salbutamol (0.086 mg/kg), and MK-801 (0.1 mg/kg), while in case of pentylenetetrazole poisoning, intratracheal administration of ipratropium bromide (0.086 mg/kg) was most effective.

About the authors

N. G. Vengerovich

State Research Institute of Military Medicine, Russian Federation of Ministry of Defense

Author for correspondence.
Email: gniiivm_2@mil.ru
Russian Federation, St. Petersburg

I. M. Drachkova

Innovative Pharmaceutical Company Silver Farm

Email: gniiivm_2@mil.ru
Russian Federation, St. Petersburg

M. A. Yudin

State Research Institute of Military Medicine, Russian Federation of Ministry of Defense

Email: gniiivm_2@mil.ru
Russian Federation, St. Petersburg

V. N. Bykov

State Research Institute of Military Medicine, Russian Federation of Ministry of Defense

Email: gniiivm_2@mil.ru
Russian Federation, St. Petersburg

A. M. Sarana

Aff3

Email: gniiivm_2@mil.ru
Russian Federation, City Hospital No. 40, St. Petersburg


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