Effect of Bone Marrow Multipotent Mesenchymal Stromal Cells on Blood and Lymphatic Vasculature in Uterine Wall of Wistar Rats during Experimental Chronic Metroendometritis


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Abstract

The study examined the effect of bone marrow multipotent mesenchymal stromal cells and their products secreted into the conditioned medium on uterine microcirculatory bed in Wistar rats during chronic inflammation. The parameters of blood and lymphatic microcirculation in the uterus changed in various directions in relation to the administration routes of biomedical cell product, which is important when the cell therapy is employed in the treatment of inflammatory-degenerative alterations in the lesser pelvis organs.

About the authors

E. G. Koroleva

Research Institute of Experimental and Clinical Lymphology, Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk

T. I. Dergacheva

Research Institute of Experimental and Clinical Lymphology, Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Author for correspondence.
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk

A. V. Shurlygina

Research Institute of Experimental and Clinical Lymphology, Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk

O. V. Poveshchenko

Research Institute of Experimental and Clinical Lymphology, Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk

S. E. Krasil’nikov

Novosibirsk Regional Clinical Oncology Health Center

Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk

V. I. Konenkov

Research Institute of Experimental and Clinical Lymphology, Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences

Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk


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