Email this article Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats
- Authors: El’chaninov A.V.1,2, Fatkhudinov T.K.1,2, Arutyunyan I.V.1, Makarov A.V.1,3, Usman N.Y.1, Mikhailova L.P.4, Lokhonina A.V.1, Botchey V.M.2, Glinkina V.V.3, Bol’shakova G.B.4
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Affiliations:
- V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Peoples’ Friendship University of Russia
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Research Institute of Human Morphology
- Issue: Vol 165, No 1 (2018)
- Pages: 136-141
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240063
- DOI: https://doi.org/10.1007/s10517-018-4115-9
- ID: 240063
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Abstract
The role of the lungs and kidneys in liver regeneration after subtotal hepatectomy was studied on a rat model. It was found that production of hepatocyte growth factor (HGF) in the lungs and kidneys and expression of cytokine genes Il1b, Il6, Il10, and tnfa significantly increased. Analysis of the dynamics of lung macrophage population showed that accumulation of HGF and the increase in the expression of cytokine genes in the lungs were accompanied by simultaneous increase in the number of CD68+ cells, which attested to the leading role of macrophages in activation of HGF synthesis in the lungs. Macrophage content in the kidneys after subtotal hepatectomy did not increase.
About the authors
A. V. El’chaninov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow
T. Kh. Fatkhudinov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia
Author for correspondence.
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow
I. V. Arutyunyan
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
A. V. Makarov
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow
N. Yu. Usman
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
L. P. Mikhailova
Research Institute of Human Morphology
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
A. V. Lokhonina
V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
V. M. Botchey
Peoples’ Friendship University of Russia
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
V. V. Glinkina
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
G. B. Bol’shakova
Research Institute of Human Morphology
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
