Email this article Isolation of Rat Olfactory Ensheathing Cells and Their Use in the Therapy of Posttraumatic Cysts of the Spinal Cord
- Authors: Stepanova O.V.1, Voronova А.D.1,2, Chadin A.V.1, Valikhov M.P.1, Abakumov M.A.2, Reshetov I.V.3, Chekhonin V.1,2
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Affiliations:
- Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation
- Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov National Research Medical University, Ministry of Health of the Russian Federation
- University Clinical Hospital No. 1, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 1 (2018)
- Pages: 132-135
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240055
- DOI: https://doi.org/10.1007/s10517-018-4114-x
- ID: 240055
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Abstract
We evaluated the efficacy of rat olfactory ensheathing cells in the therapy of experimental cysts of the spinal cord. Improvement of the motor function of the hind limbs after transplantation of the olfactory ensheathing cells into the posttraumatic spinal cord cysts rats was found. We also determined the required number of cells for transplantation and demonstrated a neuroprotective effect of this dosage. For further clinical studies, autologous tissue-specific cell preparation of olfactory ensheathing cells has to be created. Cell therapy in combination surgical and pharmacological treatment will substantially improve the quality of life of patients with posttraumatic spinal cord cysts.
About the authors
O. V. Stepanova
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: sms-34@yandex.ru
Russian Federation, Moscow
А. D. Voronova
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation; Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov National Research Medical University, Ministry of Health of the Russian Federation
Email: sms-34@yandex.ru
Russian Federation, Moscow; Moscow
A. V. Chadin
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: sms-34@yandex.ru
Russian Federation, Moscow
M. P. Valikhov
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: sms-34@yandex.ru
Russian Federation, Moscow
M. A. Abakumov
Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov National Research Medical University, Ministry of Health of the Russian Federation
Email: sms-34@yandex.ru
Russian Federation, Moscow
I. V. Reshetov
University Clinical Hospital No. 1, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Email: sms-34@yandex.ru
Russian Federation, Moscow
V.P. Chekhonin
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation; Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov National Research Medical University, Ministry of Health of the Russian Federation
Email: sms-34@yandex.ru
Russian Federation, Moscow; Moscow
