Email this article Heart Rhythm Disturbances Caused by Injection of Cholinesterase Inhibitor Physostigmine to Rats during the Early Ontogeny
- Authors: Sizonov V.А.1, Dmitrieva L.E.1
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Affiliations:
- I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Science
- Issue: Vol 165, No 1 (2018)
- Pages: 44-47
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239961
- DOI: https://doi.org/10.1007/s10517-018-4095-9
- ID: 239961
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Abstract
Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnitude, which suggests that that maturation of cholinergic structures involved in the regulation of cardiac activity is completed during the early postnatal ontogeny.
About the authors
V. А. Sizonov
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Science
Author for correspondence.
Email: sizonvladimir@yandex.ru
Russian Federation, St. Petersburg
L. E. Dmitrieva
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Science
Email: sizonvladimir@yandex.ru
Russian Federation, St. Petersburg
