Email this article Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia
- Authors: Kisrieva Y.S.1, Petushkova N.A.1, Samenkova N.F.1, Kuznetsova G.P.1, Larina O.V.1, Teryaeva N.B.2, Zgoda V.G.1, Karuzina I.I.1, Usachev D.U.2, Belyaev A.Y.2
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Affiliations:
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 1 (2018)
- Pages: 22-26
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239943
- DOI: https://doi.org/10.1007/s10517-018-4090-1
- ID: 239943
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Abstract
Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.
About the authors
Yu. S. Kisrieva
V. N. Orekhovich Research Institute of Biomedical Chemistry
Author for correspondence.
Email: juliaks@bk.ru
Russian Federation, Moscow
N. A. Petushkova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: juliaks@bk.ru
Russian Federation, Moscow
N. F. Samenkova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: juliaks@bk.ru
Russian Federation, Moscow
G. P. Kuznetsova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: juliaks@bk.ru
Russian Federation, Moscow
O. V. Larina
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: juliaks@bk.ru
Russian Federation, Moscow
N. B. Teryaeva
N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation
Email: juliaks@bk.ru
Russian Federation, Moscow
V. G. Zgoda
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: juliaks@bk.ru
Russian Federation, Moscow
I. I. Karuzina
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: juliaks@bk.ru
Russian Federation, Moscow
D. U. Usachev
N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation
Email: juliaks@bk.ru
Russian Federation, Moscow
A. Yu. Belyaev
N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation
Email: juliaks@bk.ru
Russian Federation, Moscow
