Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro
- Authors: Lyakhova I.A.1, Bryukhovetsky I.S.1,2, Kudryavtsev I.V.1, Khotimchenko Y.S.1,2, Zhidkov M.E.1, Kantemirov A.V.1
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Affiliations:
- Biomedicine School, Far-Eastern Federal University
- A. V. Zhirmunsky Institute of Marine Biology, Far-Eastern Division of the Russian Academy of Sciences
- Issue: Vol 164, No 5 (2018)
- Pages: 666-672
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239832
- DOI: https://doi.org/10.1007/s10517-018-4055-4
- ID: 239832
Cite item
Abstract
Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin and 7-phenylfascaplysin exhibited the best capacity to kill glioma C6 cells. Apoptosis was the main mechanism of glioma cell death. The cytotoxic activity of these compounds increased with prolongation of exposure to the substance and increase of its concentration. Fascaplysin derivatives modified all phases of glioma cell vital cycle. The count of viable tumor cell in G0 phase remained minimum by the end of experiment under the effects of 3-bromofascaplysin and 7-phenylfascaplysin.
About the authors
I. A. Lyakhova
Biomedicine School, Far-Eastern Federal University
Author for correspondence.
Email: liakhova.ia@dvfu.ru
Russian Federation, Vladivostok
I. S. Bryukhovetsky
Biomedicine School, Far-Eastern Federal University; A. V. Zhirmunsky Institute of Marine Biology, Far-Eastern Division of the Russian Academy of Sciences
Email: liakhova.ia@dvfu.ru
Russian Federation, Vladivostok; Vladivostok
I. V. Kudryavtsev
Biomedicine School, Far-Eastern Federal University
Email: liakhova.ia@dvfu.ru
Russian Federation, Vladivostok
Yu. S. Khotimchenko
Biomedicine School, Far-Eastern Federal University; A. V. Zhirmunsky Institute of Marine Biology, Far-Eastern Division of the Russian Academy of Sciences
Email: liakhova.ia@dvfu.ru
Russian Federation, Vladivostok; Vladivostok
M. E. Zhidkov
Biomedicine School, Far-Eastern Federal University
Email: liakhova.ia@dvfu.ru
Russian Federation, Vladivostok
A. V. Kantemirov
Biomedicine School, Far-Eastern Federal University
Email: liakhova.ia@dvfu.ru
Russian Federation, Vladivostok