Email this article Combined Action of PGRPs-Hsp70 Cytotoxic Complex with Paclitaxel Improves Outcomes of Melanoma Treatment in Mice
- Authors: Dukhanina E.A.1, Luk’yanova T.I.2, Dukhanin A.S.3, Georgieva S.G.2
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Affiliations:
- V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 164, No 5 (2018)
- Pages: 658-660
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/239822
- DOI: https://doi.org/10.1007/s10517-018-4053-6
- ID: 239822
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Abstract
We studied the effect of PGRPs-Hsp70 cytotoxic complex that is analogous to natural complex secreted by cytotoxic lymphocytes and the antitumor drug paclitaxel on the development of M3 melanoma in DBA mice. Significant inhibition of tumor growth was observed in all experimental groups by days 20 and 35 of observation; paclitaxel monotherapy was less effective than administration of PGRPs-Hsp70 cytotoxic complex and its combination with paclitaxel. Pairwise comparison of Kaplan—Meier curves showed that survival was maximum in the group receiving combined therapy with PGRPs-Hsp70 cytotoxic complex and paclitaxel in comparison with groups receiving monotherapy.
About the authors
E. A. Dukhanina
V. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: das03@rambler.ru
Russian Federation, Moscow
T. I. Luk’yanova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: das03@rambler.ru
Russian Federation, Moscow
A. S. Dukhanin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: das03@rambler.ru
Russian Federation, Moscow
S. G. Georgieva
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: das03@rambler.ru
Russian Federation, Moscow
