Email this article GABAergic Mechanism of Anticonvulsive Effect of Chemical Agent RU-1205
- Authors: Kalitin K.Y.1, Grechko O.Y.1, Spasov A.A.1,2, Sukhov A.G.3, Anisimova V.A.4, Matukhno A.E.3
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Affiliations:
- Department of Pharmacology, Volgograd State Medical University
- Volgograd Medical Science Center
- Laboratory of Experimental Neurobiology, D. I. Ivanovsky Academy of Biology and Biotechnology
- Research Institute of Physical and Organic Chemistry, Southern Federal University
- Issue: Vol 164, No 5 (2018)
- Pages: 629-635
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239797
- DOI: https://doi.org/10.1007/s10517-018-4047-4
- ID: 239797
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Abstract
The study examined the effect of 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α] benzimidazole dihydrochloride (RU-1205) on the latency of seizures provoked by corazol, bicuculline, or picrotoxin. This agent (10 and 20 mg/kg) increased the seizure latency in the experimental models of epileptogenesis. The blockers of GABAA and GABAA-ρ receptors picrotoxin and (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid, respectively, were employed to study the effects of RU-1205 on electrical activity of somatosensory cortical neurons and on formation of pathological rhythms in the rat brain. RU-1205 inhibited the focal background rhythm and eliminated the epileptiform activity, which can be mediated by interaction with GABAA receptors.
About the authors
K. Yu. Kalitin
Department of Pharmacology, Volgograd State Medical University
Author for correspondence.
Email: kkonst8@yandex.ru
Russian Federation, Volgograd
O. Yu. Grechko
Department of Pharmacology, Volgograd State Medical University
Email: kkonst8@yandex.ru
Russian Federation, Volgograd
A. A. Spasov
Department of Pharmacology, Volgograd State Medical University; Volgograd Medical Science Center
Email: kkonst8@yandex.ru
Russian Federation, Volgograd; Volgograd
A. G. Sukhov
Laboratory of Experimental Neurobiology, D. I. Ivanovsky Academy of Biology and Biotechnology
Email: kkonst8@yandex.ru
Russian Federation, Rostov-on-Don
V. A. Anisimova
Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: kkonst8@yandex.ru
Russian Federation, Rostov-on-Don
A. E. Matukhno
Laboratory of Experimental Neurobiology, D. I. Ivanovsky Academy of Biology and Biotechnology
Email: kkonst8@yandex.ru
Russian Federation, Rostov-on-Don
