Email this article Experimental Analysis of the Efficacy of Dihydroquercetin on the Model of Chronic Nonbacterial Inflammation of the Prostatic Gland
- Authors: Borovskaya T.G.1, Kamalova S.I.1, Polyektova M.E.1, Mashanova V.A.1, Vychuzhanina A.V.1, Kseneva S.I.1, Plotnikov M.B.1, Goldberg V.E.2
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
- Tomsk Research Institute of Oncology, Tomsk National Medical Research Center
- Issue: Vol 164, No 5 (2018)
- Pages: 617-619
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239788
- DOI: https://doi.org/10.1007/s10517-018-4044-7
- ID: 239788
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Abstract
We studied the efficiency of dihydroquercetin on the model of chronic nonbacterial inflammation of the prostatic gland in rats. It was found that administration of dihydroquercetin was followed by a significant decrease in the area of the connective tissue in the prostatic gland to initial levels, which attested to antifibrotic properties of this oxidant. Additionally, the substance prevented the development of atrophy of acinus epithelium. After administration of reference drug Prostamol Uno, only moderate antifibrotic effects were observed.
About the authors
T. G. Borovskaya
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Author for correspondence.
Email: repropharm@yandex.ru
Russian Federation, Moscow
S. I. Kamalova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Moscow
M. E. Polyektova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Moscow
V. A. Mashanova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Moscow
A. V. Vychuzhanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Moscow
S. I. Kseneva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Moscow
M. B. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Medical Research Center, Russian Academy of Sciences
Email: repropharm@yandex.ru
Russian Federation, Moscow
V. E. Goldberg
Tomsk Research Institute of Oncology, Tomsk National Medical Research Center
Email: repropharm@yandex.ru
Russian Federation, Tomsk
