Evaluation of DNA Damage in Experimental Preeclampsia by Comet Assay

S. A. Kolesnikova; A. I. Eremina; M. V. Kustova; E. A. Muzyko; G. P. Dudchenko; V. N. Perfilova; V. Ye. Verovskii; I. N. Tyurenkov; O. V. Ostrovskii

doi:10.1007/s10517-018-4041-x

Evaluation of DNA Damage in Experimental Preeclampsia by Comet Assay

Authors: Kolesnikova S.A.¹, Eremina A.I.¹, Kustova M.V.¹, Muzyko E.A.¹, Dudchenko G.P.¹, Perfilova V.N.¹, Verovskii V.Y.¹, Tyurenkov I.N.², Ostrovskii O.V.¹
Affiliations:
1. Department of Theoretical Biochemistry with Course of Clinical Biochemistry
2. Department of Pharmacology and Biopharmaceutics, Doctor Improvement Faculty, Volgograd State Medical University of the Ministry of Health of Russian Federation
Issue: Vol 164, No 5 (2018)
Pages: 605-608
Section: Biophysics and Biochemistry
URL: https://journals.rcsi.science/0007-4888/article/view/239781
DOI: https://doi.org/10.1007/s10517-018-4041-x
ID: 239781

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Abstract

Experimental preeclampsia induced by substitution of drinking water with 1.8% NaCl during pregnancy was associated with an increase in the level of DNA damage in fetal brain and placenta measured by DNA comet assay by 35.7 and 27.8 times, respectively, in comparison with physiological pregnancy.