Email this article Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny
- Authors: Tsomartova D.A.1, Yaglova N.V.1, Yaglov V.V.1
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Affiliations:
- Research Institute of Human Morphology
- Issue: Vol 164, No 4 (2018)
- Pages: 493-496
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239707
- DOI: https://doi.org/10.1007/s10517-018-4019-8
- ID: 239707
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Abstract
Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical β-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development. Suppression of the Wnt pathway in zona fasciculata promotes its regeneration after DDT-induced blood circulation disorders and cell death.
About the authors
D. A. Tsomartova
Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
N. V. Yaglova
Research Institute of Human Morphology
Author for correspondence.
Email: yaglova@mail.ru
Russian Federation, Moscow
V. V. Yaglov
Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
