Experimental Modeling of Alcohol-Induced Liver Cirrhosis in Rats

A. E. Antushevich; A. E. Antushevich; A. N. Grebenyuk; D. A. Khalyutin; A. A. Yartseva

doi:10.1007/s10517-018-4000-6

Experimental Modeling of Alcohol-Induced Liver Cirrhosis in Rats

Authors: Antushevich A.E.¹, Antushevich A.E.¹, Grebenyuk A.N.¹, Khalyutin D.A.¹, Yartseva A.A.¹
Affiliations:
1. S. M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation
Issue: Vol 164, No 3 (2018)
Pages: 404-407
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/239650
DOI: https://doi.org/10.1007/s10517-018-4000-6
ID: 239650

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Abstract

An experimental model of alcohol-induced liver cirrhosis in white outbred rats was developed: intragastric administration of 40% ethanol (3 g/kg) every other day for 3 weeks and simultaneous intraperitoneal administration of 1% of N-nitrozodimethylamine (5 mg/kg) for 4 consecutive days of each week.