Potentiation of Otoprotective Effect of Hydrocortisone Immobilized on Povidone Nanoparticles under Conditions of Intravenous Injection


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Abstract

The otoprotective effect of immobilized hydrocortisone was studied on the model of acute acoustic injury to the auditory analyzer in male Wistar rats. The effects of true solution and suspension where polyvinylpyrrolidone particles (100-500 nm) served as dispersed phase (hydrocortisone concentration 5 mg/kg). The agents were administered immediately after continuous acoustic stimulation: 5 kHz tone, 110 dB for 2 h. The hearing status was evaluated by the amplitude of otoacoustic emission at the distortion product frequency (4-6.4 kHz) 1 and 24 h and 7 days after acoustic stimulation. Single injection of hydrocortisone suspension caused a more pronounced therapeutic effect within 1 day after acoustic stimulation.

About the authors

A. A. Panevin

V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation; I. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation

Author for correspondence.
Email: apanevin86@mail.ru
Russian Federation, St. Petersburg; St. Petersburg

S. G. Zhuravskii

V. A. Almazov National Medical Research Center, Ministry of Health of the Russian Federation; I. P. Pavlov First St. Petersburg State Medical University, Ministry of Health of the Russian Federation

Email: apanevin86@mail.ru
Russian Federation, St. Petersburg; St. Petersburg

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