Email this article Particular Role of JAK/STAT3 Signaling in Functional Control of Mesenchymal Progenitor Cells
- Authors: Zyuz’kov G.N.1,2, Udut E.V.1, Miroshnichenko L.A.1, Polyakova T.Y.1, Simanina E.V.1, Stavrova L.A.1, Chaikovskii A.V.1, Agafonov V.I.1, Borodulina E.V.1, Timofeev M.S.1, Zyuz’kova Y.N.1, Danilets M.G.1, Zhdanov V.V.1, Udut V.V.1,2
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
- Issue: Vol 164, No 3 (2018)
- Pages: 316-319
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239574
- DOI: https://doi.org/10.1007/s10517-018-3980-6
- ID: 239574
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Abstract
The role of JAK/STAT3-mediated signaling pathway in the realization of the growth potential of mesenchymal precursor cells was examined in vitro. The stimulating role of JAKs and STAT3 towards proliferating activity of progenitor cells and their different role in the regulation of differentiation of the progenitor elements were demonstrated. Inhibitors of JAKs and STAT3 reduced the yield of fibroblast CFU and their mitotic activity. Blockade of JAKs accelerated and selective inactivation of STAT3 decelerated differentiation of progenitor cells.
About the authors
G. N. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
Author for correspondence.
Email: zgn@pharmso.ru
Russian Federation, Tomsk; Tomsk
E. V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
L. A. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
T. Yu. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
E. V. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
L. A. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
A. V. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
V. I. Agafonov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
E. V. Borodulina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
M. S. Timofeev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
Yu. N. Zyuz’kova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
M. G. Danilets
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
V. V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
V. V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; Laboratory of Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University
Email: zgn@pharmso.ru
Russian Federation, Tomsk; Tomsk
