Inducible NO Synthase mRNA Expression and Infiltration of Rats Myocardium with Inflammatory Cells in 2-4 Hours after Modeled Permanent Ischemia or Ischemia/Reperfusion
- Authors: Ivanov E.V.1, Berdalin A.B.1, Volkova Y.L.1, Markov M.A.1, Davydova M.P.1, Gavrilova S.1
-
Affiliations:
- Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
- Issue: Vol 164, No 3 (2018)
- Pages: 293-297
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239562
- DOI: https://doi.org/10.1007/s10517-018-3975-3
- ID: 239562
Cite item
Abstract
Expression of inducible NO-synthase mRNA and myocardial infiltration with neutrophils were studied in rats with modeled permanent ischemia and ischemia/reperfusion models. Expression of inducible NO synthase mRNA in the ischemic region increased significantly in 3, 3.5, and 4 h in modeled ischemia/reperfusion and in 3.5 and 4 h in permanent ischemia. Myocardial infiltration with neutrophils was significantly higher than in intact controls throughout the experiment without significant intergroup differences. In non-ischemic myocardium, enhanced expression of inducible NO synthase mRNA and moderate neutrophilic-lymphocytic myocardial infiltration were also observed in 3.5, and 4 h after ischemia.
About the authors
E. V. Ivanov
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: ivanovev101@gmail.com
Russian Federation, Moscow
A. B. Berdalin
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: ivanovev101@gmail.com
Russian Federation, Moscow
Yu. L. Volkova
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: ivanovev101@gmail.com
Russian Federation, Moscow
M. A. Markov
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: ivanovev101@gmail.com
Russian Federation, Moscow
M. P. Davydova
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: ivanovev101@gmail.com
Russian Federation, Moscow
S.A. Gavrilova
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Email: ivanovev101@gmail.com
Russian Federation, Moscow