DAI-1 Receptor Expression in Placenta in Earlyand Late-Onset Preeclampsia


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DAI-1 receptor (DNA-dependent activator of IFN-regulatory factors; DLM-1/ZBP-1) is an innate immunity cytoplasmic receptor of the DNA-recognition receptor class of antiviral immunity. DAI-1 expression reflects the severity of the inflammatory response that plays the key role in the pathogenesis of pregnancy complications. We studied DAI-1 receptor expression in the placental villi in early- and late-onset preeclampsia. In case of early-onset preeclampsia DAI-1 staining intensity was lower (p=0.01), and in case of late preeclampsia — significantly higher (p<0.005) than in the reference groups at the corresponding gestational age. There was revealed a correlation between the decrease in DAI-1 receptor expression and the severity of disease progression.

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N. Nizyaeva

V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

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Email: niziaeva@gmail.com
俄罗斯联邦, Moscow

G. Kulikova

V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: niziaeva@gmail.com
俄罗斯联邦, Moscow

M. Nagovitsyna

V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: niziaeva@gmail.com
俄罗斯联邦, Moscow

G. Khlestova

V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: niziaeva@gmail.com
俄罗斯联邦, Moscow

M. Yushina

V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: niziaeva@gmail.com
俄罗斯联邦, Moscow

O. Baev

V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: niziaeva@gmail.com
俄罗斯联邦, Moscow

A. Shchegolev

V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: niziaeva@gmail.com
俄罗斯联邦, Moscow

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