DAI-1 Receptor Expression in Placenta in Earlyand Late-Onset Preeclampsia
- 作者: Nizyaeva N.V.1, Kulikova G.V.1, Nagovitsyna M.N.1, Khlestova G.V.1, Yushina M.N.1, Baev O.R.1, Shchegolev A.I.1
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隶属关系:
- V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- 期: 卷 164, 编号 1 (2017)
- 页面: 109-114
- 栏目: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/239408
- DOI: https://doi.org/10.1007/s10517-017-3936-2
- ID: 239408
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详细
DAI-1 receptor (DNA-dependent activator of IFN-regulatory factors; DLM-1/ZBP-1) is an innate immunity cytoplasmic receptor of the DNA-recognition receptor class of antiviral immunity. DAI-1 expression reflects the severity of the inflammatory response that plays the key role in the pathogenesis of pregnancy complications. We studied DAI-1 receptor expression in the placental villi in early- and late-onset preeclampsia. In case of early-onset preeclampsia DAI-1 staining intensity was lower (p=0.01), and in case of late preeclampsia — significantly higher (p<0.005) than in the reference groups at the corresponding gestational age. There was revealed a correlation between the decrease in DAI-1 receptor expression and the severity of disease progression.
作者简介
N. Nizyaeva
V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: niziaeva@gmail.com
俄罗斯联邦, Moscow
G. Kulikova
V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: niziaeva@gmail.com
俄罗斯联邦, Moscow
M. Nagovitsyna
V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: niziaeva@gmail.com
俄罗斯联邦, Moscow
G. Khlestova
V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: niziaeva@gmail.com
俄罗斯联邦, Moscow
M. Yushina
V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: niziaeva@gmail.com
俄罗斯联邦, Moscow
O. Baev
V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: niziaeva@gmail.com
俄罗斯联邦, Moscow
A. Shchegolev
V. I. Kulakov Research Centre for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: niziaeva@gmail.com
俄罗斯联邦, Moscow
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