Email this article Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland
- Authors: Khavinson V.K.1,2, Kopylov A.T.1, Vaskovsky B.V.1, Ryzhak G.A.1, Lin’kova N.S.1,3
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Affiliations:
- Research Centre St. Petersburg Institute of Bioregulation and Gerontology
- I. P. Pavlov Institute of Physiology of Russian Academy of Sciences
- Peter the Great St. Petersburg Polytechnic University
- Issue: Vol 164, No 1 (2017)
- Pages: 41-43
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/239349
- DOI: https://doi.org/10.1007/s10517-017-3922-8
- ID: 239349
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Abstract
The polypeptide complex of the epiphysis and the peptide AEDG, constructed on the basis of its amino acid analysis, exert similar biological effects. Both bioregulators normalize melatonin synthesis in the pineal gland, functioning of the brain, eye retina, cardiovascular, endocrine, and immune systems; they also act as antioxidants, stress-protectors, and geroprotectors. Within the epiphysis polypeptide complex, free amino acids (3.26%), dipeptides (23.19%), tripeptides (50.72%), tetrapeptides (22.10%), and pentapeptides (0.72%) were revealed by mass spectrometry and HPLC. Peptide AEDG was detected among the tetrapeptides of the epiphysis polypeptide complex by selective reaction monitoring method. The biological effects of the epiphysis polypeptide complex are determined by the effect of its component AEDG.
About the authors
V. Kh. Khavinson
Research Centre St. Petersburg Institute of Bioregulation and Gerontology; I. P. Pavlov Institute of Physiology of Russian Academy of Sciences
Author for correspondence.
Email: khavinson@gerontology.ru
Russian Federation, St. Petersburg; St. Petersburg
A. T. Kopylov
Research Centre St. Petersburg Institute of Bioregulation and Gerontology
Email: khavinson@gerontology.ru
Russian Federation, St. Petersburg
B. V. Vaskovsky
Research Centre St. Petersburg Institute of Bioregulation and Gerontology
Email: khavinson@gerontology.ru
Russian Federation, St. Petersburg
G. A. Ryzhak
Research Centre St. Petersburg Institute of Bioregulation and Gerontology
Email: khavinson@gerontology.ru
Russian Federation, St. Petersburg
N. S. Lin’kova
Research Centre St. Petersburg Institute of Bioregulation and Gerontology; Peter the Great St. Petersburg Polytechnic University
Email: khavinson@gerontology.ru
Russian Federation, St. Petersburg; St. Petersburg
