Peculiarities of the Development of the Myocardial Infarction in ISIAH Rats

Abstract

We studied peculiarities of the development of myocardial infarction in rats with inherited stress-induced arterial hypertension (ISIAH rats). The control group consisted of Wistar rats. Occlusion of the left coronary artery (30 min) followed by reperfusion (120 min) was performed. The infarct size was determined relative to the risk zone by staining with 1% triphenyltetrazolium. BP, blood filling, and blood flow in the caudal vessels were measured. The infarct size was 31.5±3.0% of the risk zone in Wistar rats and 47.9±4.4% in ISIAH rats (p=0.026). No correlations of infarction size and BP or HR were found at the study stages. In ISIAH rats, local 30-min ischemia followed by 120-min reperfusion caused greater myocardial infarction that did not depend on BP or HR.