Myocardial Protection against Ischemic and Reperfusion Injuries (Experimental Study)
- Authors: Mandel’ I.A.1, Podoksenov A.Y.2, Sukhodolo I.V.3, Podoksenov Y.K.2,3, Svirko Y.S.2,3, Kamenshchikov N.O.2, Mikheev S.L.2,3, Sementsov A.S.2, Rogovskaya Y.V.2, An D.A.3, Shipulin V.M.2,3, Maslov L.N.2
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Affiliations:
- Federal Research Clinical Center, Federal Medical-Biological Agency
- Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 164, No 1 (2017)
- Pages: 21-25
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239329
- DOI: https://doi.org/10.1007/s10517-017-3917-5
- ID: 239329
Cite item
Abstract
The effects of hypoxic, hyperoxic, and hypoxic-hyperoxic preconditioning were examined in the prospective study on narcotized and artificially ventilated rabbits. Under artificial circulation, acute myocardial ischemia was modeled by ligation of anterior descending coronary artery, which was followed by reperfusion. The degree of ventricular arrhythmias was assessed, and the ischemic area was evaluated in percent of the area at risk. Microscopic characterization of the myocardium was employed to assess the cardioprotective effect of hypoxic and/or hyperoxic preconditioning. According to Kruskal—Wallis test, the greatest resistance of the myocardium to ischemic and reperfusion injury was observed after hypoxic-hyperoxic preconditioning (H=42.459; p=0.009). The rabbits subjected to this type of preconditioning demonstrated the least damaged myocardium in comparison with nonconditioned controls.
About the authors
I. A. Mandel’
Federal Research Clinical Center, Federal Medical-Biological Agency
Author for correspondence.
Email: irina.a.mandel@gmail.com
Russian Federation, Moscow
A. Yu. Podoksenov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk
I. V. Sukhodolo
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk
Yu. K. Podoksenov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk; Tomsk
Yu. S. Svirko
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk; Tomsk
N. O. Kamenshchikov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk
S. L. Mikheev
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk; Tomsk
A. S. Sementsov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk
Yu. V. Rogovskaya
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk
D. A. An
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk
V. M. Shipulin
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk; Tomsk
L. N. Maslov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Russian Federation, Tomsk