Selectivity in Physiological Action of Nitric Oxide: A Hypothetical Mechanism
- Authors: Titov V.Y.1,2, Dolgorukova A.M.2, Petrov V.A.1, Osipov A.N.1
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Affiliations:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Federal Research Centre All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
- Issue: Vol 163, No 6 (2017)
- Pages: 726-730
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239219
- DOI: https://doi.org/10.1007/s10517-017-3890-z
- ID: 239219
Cite item
Abstract
The study showed that dinitrosyl iron complex (NO)2Fe(RS)2 containing the thiolate ligands, which is the basic physiological donor of NO, can transfer NO to other molecule only at the moment of rearrangement. This rearrangement can occur during interaction of the complex with more effective iron chelators than the thiolate ligands. In the absence of NO trap, a new complex is formed with a new ligand. NO transfer to a trap can also occur under the action of the agents such as mercury salts or ROS, which interact with the thiolate ligands. Probably, the ligands in the dinitrosyl iron complexes are the structures responsible for interaction of these complexes with physiological targets and for specificity and effectiveness of this interaction.
About the authors
V. Yu. Titov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation; Federal Research Centre All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
Author for correspondence.
Email: vtitov43@yandex.ru
Russian Federation, Moscow; Sergiev Posad, Moscow Region
A. M. Dolgorukova
Federal Research Centre All-Russian Research and Technology Institute for Poultry Industry, Russian Academy of Sciences
Email: vtitov43@yandex.ru
Russian Federation, Sergiev Posad, Moscow Region
V. A. Petrov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Russian Federation, Moscow
A. N. Osipov
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: vtitov43@yandex.ru
Russian Federation, Moscow