Email this article Role of β2-Adrenoreceptors in Adrenergic Anti-Inflammatory Mechanism in Sepsis
- Authors: Zabrodskii P.F.1, Gromov M.S.1, Maslyakov V.V.1
-
Affiliations:
- REAVIZ Saratov Medical University
- Issue: Vol 163, No 6 (2017)
- Pages: 710-713
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/239213
- DOI: https://doi.org/10.1007/s10517-017-3886-8
- ID: 239213
Cite item
Open Access
Access granted
Subscription Access
Abstract
Experiments on random-bred albino mice showed that of β2-adrenoreceptor agonist hexaprenaline sulfate significantly reduced mortality of mice from experimental sepsis (intraperitoneal administration of E. coli) in 4 and 24 h after modeling by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, and IL-6. The antagonist of β2AR ICI-118,551 eliminated this effect.
About the authors
P. F. Zabrodskii
REAVIZ Saratov Medical University
Author for correspondence.
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
M. S. Gromov
REAVIZ Saratov Medical University
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
V. V. Maslyakov
REAVIZ Saratov Medical University
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
