Experimental Study of Yeast RNA Preparation as a Possible Radioprotective Agent for Radiotherapy of Malignant Tumors
- Authors: Nikolin V.P.1, Bogachev S.S.1, Popova N.A.1,2, Tornuev Y.V.3, Vinogradova E.V.3
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Affiliations:
- Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk State University
- Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 163, No 5 (2017)
- Pages: 639-642
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239146
- DOI: https://doi.org/10.1007/s10517-017-3868-x
- ID: 239146
Cite item
Abstract
We studied radioprotective effects of a preparation based on yeast RNA and its influence on therapeutic efficiency of ionizing radiation against transplanted tumors. Parenteral administration of yeast RNA preparation to mice in a dose of 10 mg 1 h prior to exposure to ionizing γ-radiation (137Cs) in a lethal dose (LD80/30) increased 30-day survival by 66%; by day 80, 80% of animals survived (vs. 2.5% in the control). Whole-body exposure to ionizing γ-radiation in a dose of 7 Gy significantly increased the mean lifespan of mice with experimental lung metastases or intraperitoneally transplanted leukemia L-1210 by 42 and 20.8%, respectively. RNA preparation injected to the mice with tumors 1 h before irradiation did not affect the therapeutic efficiency of ionizing radiation or significantly potentiated it (in mice with transplanted leukemia L-1210). These results suggest that yeast RNA preparation protects healthy tissues during radiotherapy of malignant tumors.
About the authors
V. P. Nikolin
Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
S. S. Bogachev
Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
N. A. Popova
Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk State University
Email: pathol@inbox.ru
Russian Federation, Novosibirsk; Novosibirsk
Yu. V. Tornuev
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
E. V. Vinogradova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
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