Activation of Microglyocytes in the Anterior Horns of Rat Spinal Cord after Administration of Bacterial Lipopolysaccharide
- Authors: Kolos E.A.1, Korzhevskii D.E.1
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Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 163, No 4 (2017)
- Pages: 515-518
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239062
- DOI: https://doi.org/10.1007/s10517-017-3841-8
- ID: 239062
Cite item
Abstract
We studied the reaction of the microglia of the anterior horns of the rat spinal cord to intraperitoneal administration of bacterial LPS. Immunohistochemical analysis showed that acute systemic inflammation leads to activation of more than half of microglial cells as soon as in 24 h after LPS injection, while the total number of microglial cells does not change significantly. It was hypothesized that activated microglial cells are involved in the reorganization of synaptic connections, but do not have a neurotoxic effect.
About the authors
E. A. Kolos
Institute of Experimental Medicine
Author for correspondence.
Email: iemmorphol@yandex.ru
Russian Federation, St. Petersburg
D. E. Korzhevskii
Institute of Experimental Medicine
Email: iemmorphol@yandex.ru
Russian Federation, St. Petersburg