Morphological Analysis of Biocompatibility of Autologous Bone Marrow Mononuclear Cells with Synthetic Polyethylene Terephthalate Scaffold
- Authors: Gilevich I.V.1, Polyakov I.S.1, Porkhanov V.A.1, Chekhonin V.P.2
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Affiliations:
- Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 163, No 3 (2017)
- Pages: 400-404
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238935
- DOI: https://doi.org/10.1007/s10517-017-3813-z
- ID: 238935
Cite item
Abstract
We studied the properties of a tissue-engineered trachea consisting of a polyethylene terephthalate scaffold populated with autologous bone marrow mononuclear cells. The tissue-engineered constructs were obtained before surgery, during the postoperative period, and during autopsy. Cytomorphological analysis during the postoperative period showed the presence of mesenchymal stem cells on the inner surface of the implant on day 3 after surgery and cells of the respiratory epithelium on day 10-14. In autopsy samples, single epithelial cells, endothelial cells, and basal cells were found. Biocompatibility of the tissue-engineered trachea with autologous mononuclear cells of the patient was demonstrated.
About the authors
I. V. Gilevich
Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
Author for correspondence.
Email: giliv@list.ru
Russian Federation, Krasnodar
I. S. Polyakov
Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
Email: giliv@list.ru
Russian Federation, Krasnodar
V. A. Porkhanov
Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
Email: giliv@list.ru
Russian Federation, Krasnodar
V. P. Chekhonin
N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: giliv@list.ru
Russian Federation, Moscow
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