Metabolic Restructuring in the Liver under Conditions of Endogenous Intoxication
- Authors: Vlasov A.P.1, Kamkina O.V.2, Trofimov V.A.1, Vlasova T.I.1, Abramova S.V.1, Bolotskikh V.A.3
- 
							Affiliations: 
							- N. P. Oared Mordovian State University
- N. I. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation
- N. N. Burdenko Voronezh State Medical Academy
 
- Issue: Vol 163, No 3 (2017)
- Pages: 317-320
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238851
- DOI: https://doi.org/10.1007/s10517-017-3793-z
- ID: 238851
Cite item
Abstract
Significant metabolic alterations in the liver were observed in dogs with modeled acute peritonitis. These changes significantly impaired detoxification function of the liver, which was seen from the increase in the titer of toxic products in the early post-surgery period not only in the lymph, but also in the blood plasma. The key pathogenic mechanism leading to acute liver failure is destabilization of cell membrane resulting from LPO, phospholipase activity, and tissue hypoxia. Activation of LPO and increase in phospholipase activity in the liver tissues were observed within 12 h after peritonitis modeling.
About the authors
A. P. Vlasov
N. P. Oared Mordovian State University
							Author for correspondence.
							Email: vap.61@mail.ru
				                					                																			                												                	Russian Federation, 							Saransk, Republic of Mordovia						
O. V. Kamkina
N. I. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation
														Email: vap.61@mail.ru
				                					                																			                												                	Russian Federation, 							Moscow						
V. A. Trofimov
N. P. Oared Mordovian State University
														Email: vap.61@mail.ru
				                					                																			                												                	Russian Federation, 							Saransk, Republic of Mordovia						
T. I. Vlasova
N. P. Oared Mordovian State University
														Email: vap.61@mail.ru
				                					                																			                												                	Russian Federation, 							Saransk, Republic of Mordovia						
S. V. Abramova
N. P. Oared Mordovian State University
														Email: vap.61@mail.ru
				                					                																			                												                	Russian Federation, 							Saransk, Republic of Mordovia						
V. A. Bolotskikh
N. N. Burdenko Voronezh State Medical Academy
														Email: vap.61@mail.ru
				                					                																			                												                	Russian Federation, 							Voronezh						
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