Effects of Chronic Tobacco Smoking on the Distribution of Tachykinin Receptors in Rat Pial Arteries
- Autores: Zakharchuk N.V.1, Chertok V.M.2, Nevzorova V.A.1, Gonchar E.Y.1
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Afiliações:
- Department of Hospital Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
- Department of Human Anatomy
- Edição: Volume 163, Nº 3 (2017)
- Páginas: 313-316
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238847
- DOI: https://doi.org/10.1007/s10517-017-3792-0
- ID: 238847
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Resumo
Pial arteries of different diameter were studied in intact rats and after 6-month modeling of chronic tobacco smoking in rats. Expression of tachykinin NK1 receptors in pial arteries was studied by biomicroscopy and immunohistochemical methods. Chronic tobacco smoking induced considerable reorganizations of the arterial bed. The intensity of changes depended on the diameter of vessels. In small pial vessels that directly participate in the blood supply to the brain, pronounced vasodilatation and enhanced expression of NK1 receptors in the endothelium mediating the effects of substance P were observed; the number of these vessels also increased. The intensity of the response to tobacco smoke components decreased with increasing vessel diameter.
Sobre autores
N. Zakharchuk
Department of Hospital Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: zaharchuknat@mail.ru
Rússia, Vladivostok
V. Chertok
Department of Human Anatomy
Email: zaharchuknat@mail.ru
Rússia, Vladivostok
V. Nevzorova
Department of Hospital Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: zaharchuknat@mail.ru
Rússia, Vladivostok
E. Gonchar
Department of Hospital Therapy and Instrumental Diagnostics, Pacific State Medical University, Ministry of Health of the Russian Federation
Email: zaharchuknat@mail.ru
Rússia, Vladivostok
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