Effect of Progressive Heart Failure on Cerebral Hemodynamics and Monoamine Metabolism in CNS
- Authors: Mamalyga M.L.1, Mamalyga L.M.1
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Affiliations:
- Department of Human and Animal Anatomy and Physiology, Moscow State Pedagogical University
- Issue: Vol 163, No 3 (2017)
- Pages: 307-312
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238846
- DOI: https://doi.org/10.1007/s10517-017-3791-1
- ID: 238846
Cite item
Abstract
Compensated and decompensated heart failure are characterized by different associations of disorders in the brain and heart. In compensated heart failure, the blood flow in the common carotid and basilar arteries does not change. Exacerbation of heart failure leads to severe decompensation and is accompanied by a decrease in blood flow in the carotid and basilar arteries. Changes in monoamine content occurring in the brain at different stages of heart failure are determined by various factors. The functional exercise test showed unequal monoamine-synthesizing capacities of the brain in compensated and decompensated heart failure. Reduced capacity of the monoaminergic systems in decompensated heart failure probably leads to overstrain of the central regulatory mechanisms, their gradual exhaustion, and failure of the compensatory mechanisms, which contributes to progression of heart failure.
About the authors
M. L. Mamalyga
Department of Human and Animal Anatomy and Physiology, Moscow State Pedagogical University
Author for correspondence.
Email: mamalyga_49@mail.ru
Russian Federation, Moscow
L. M. Mamalyga
Department of Human and Animal Anatomy and Physiology, Moscow State Pedagogical University
Email: mamalyga_49@mail.ru
Russian Federation, Moscow