Email this article Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis
- Authors: Zabrodskii P.F.1, Gromov M.S.1, Maslyakov V.V.1
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Affiliations:
- Saratov Branch of Samara Medical Institute REAVIZ
- Issue: Vol 162, No 6 (2017)
- Pages: 750-753
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238524
- DOI: https://doi.org/10.1007/s10517-017-3704-3
- ID: 238524
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Abstract
Experiments on random-bred albino mice showed that M1 muscarinic acetylcholine receptor agonist (TBPB) and α7n-acetylcholine receptor agonist (GTS-21) significantly reduced mortality of mice with experimental sepsis (intraperitoneally administration of E. coli) in 4 and 24 h after modeling by reducing blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. Combined treatment with TBPB and GTS-21 determined their additive effect.
About the authors
P. F. Zabrodskii
Saratov Branch of Samara Medical Institute REAVIZ
Author for correspondence.
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
M. S. Gromov
Saratov Branch of Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
V. V. Maslyakov
Saratov Branch of Samara Medical Institute REAVIZ
Email: pfzabrodsky@gmail.com
Russian Federation, Saratov
