Effect of Metal-Containing Nanocomposites on Functional Status of the Thymus in Experimental Animals

V. I. Dubrovina; S. V. Balakhonov; V. V. Voitkova; S. A. Vityazeva; T. P. Starovoitova; K. M. Korytov; G. F. Prozorova; G. P. Aleksandrova; S. I. Kolesnikov

doi:10.1007/s10517-017-3683-4

Effect of Metal-Containing Nanocomposites on Functional Status of the Thymus in Experimental Animals

Authors: Dubrovina V.I.¹, Balakhonov S.V.¹, Voitkova V.V.¹, Vityazeva S.A.¹, Starovoitova T.P.¹, Korytov K.M.¹, Prozorova G.F.², Aleksandrova G.P.², Kolesnikov S.I.³
Affiliations:
1. Irkutsk Anti-Plague Research Institute of Siberia and the Far East
2. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Sciences
3. Research Center of Family Health and Reproduction Problems
Issue: Vol 162, No 5 (2017)
Pages: 666-670
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238445
DOI: https://doi.org/10.1007/s10517-017-3683-4
ID: 238445

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Abstract

The effects of nanostructurized composites argentogalactomannan and argento-poly-1-vinyl-1,2,4-triasole on the kinetics of T cell maturation in the thymus of albino mice were studied. These nanocomposites stimulated the formation of CD3⁺CD4⁺CD8^— and CD3⁺CD4^—CD8⁺ cells from CD3^—CD4^—CD8^— cells, the effect of argentogalactomannan was more potent. The efficiency of these compounds as agents improving the defense potential deserves special studies.