Correction of Abnormalities Provoked by Long-Term Alcoholization with Hypoxic-Hyperoxic Training

Abstract

Free radical oxidation in the liver and skeletal muscles as well as stress behavior were examined in rats subjected to a gradual long-term alcoholization with elevated ethanol content from 10 to 40% followed by correction of alcohol-induced disturbances with hypoxic-hyperoxic training. The elevated plus-maze test revealed increased anxiety and appearance of risky behavior in alcoholized rats in the absence of changes in motor and orientation activity. In the liver and skeletal muscles of alcoholized rats, free radical oxidation processes were decompensated despite activation of antioxidant enzymes. Adaptation to intermittent hypoxia-hyperoxia during last two weeks of alcoholization exerted a protective effect against ethanol-induced oxidative stress: reduced anxious and risk behavior, normalized tissue tolerance of free radical oxidation processes, and restored the level of protective proteins.