Relationship between the Level of Circulating CD45+ Platelets and Development of Restenosis after Implantation of Drug-Eluting Stents to Patients with Coronary Heart Disease
- Authors: Gabbasov Z.A.1, Kozlov S.G.1, Byazrova S.V.1, Mel’nikov I.S.1, Saburova O.S.1
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Affiliations:
- Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
- Issue: Vol 162, No 4 (2017)
- Pages: 524-527
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238345
- DOI: https://doi.org/10.1007/s10517-017-3653-x
- ID: 238345
Cite item
Abstract
The study was carried out in 126 patients with stable angina pectoris, who underwent elective coronary artery stenting with drug-eluting stents and follow-up angiography within 6-12 months thereafter. Five significant risk factors of restenosis were identified by binary comparisons of different variables. The logistic regression equation that included the level of CD45-positive platelets, diabetes, small vessel stenting, number of simultaneously implanted stents in one patient, and lesion length demonstrates the highest level of prediction of in-stent restenosis (OR=22.8; p<0.001). ROC-analysis demonstrated high prognostic value of the logit model (area under ROC curve 0.87, p<0.001). The data suggest that a close relationship exists between the development of restenosis and the level of circulating CD45+ platelets.
About the authors
Z. A. Gabbasov
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Author for correspondence.
Email: zufargabbasov@yandex.ru
Russian Federation, Moscow
S. G. Kozlov
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: zufargabbasov@yandex.ru
Russian Federation, Moscow
S. V. Byazrova
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: zufargabbasov@yandex.ru
Russian Federation, Moscow
I. S. Mel’nikov
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: zufargabbasov@yandex.ru
Russian Federation, Moscow
O. S. Saburova
Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation
Email: zufargabbasov@yandex.ru
Russian Federation, Moscow