Systemic Amyloidosis Model on Young Mice

V. A. Kozlov; S. P. Sapozhnikov; P. B. Karyshev; A. I. Sheptukhina; O. V. Nikolaeva

doi:10.1007/s10517-017-3652-y

Systemic Amyloidosis Model on Young Mice

Authors: Kozlov V.A.¹, Sapozhnikov S.P.¹, Karyshev P.B.², Sheptukhina A.I.¹, Nikolaeva O.V.¹
Affiliations:
1. Department of Medical Biology with a Course of Microbiology and Virology
2. Department of Common, Clinical Pathology and Forensic Medicine, I. N. Ulyanov Chuvash State University
Issue: Vol 162, No 4 (2017)
Pages: 520-523
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/238338
DOI: https://doi.org/10.1007/s10517-017-3652-y
ID: 238338

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Abstract

Subcutaneous daily injection (with neglect of aseptics) of 0.5 ml solution of soybean cream substitute (10% volume in distilled water) during 30 days caused systemic amyloidosis in 30-day-old mice. All the known methods for induction of systemic amyloidosis are based on the use of old animals, as senile tissue bradytrophy allows effective simulation of amyloidosis.