Email this article Impairment of Energy-Dependent Processes in the Muscle Tissue as a Pathogenetic Mechanism of Statin-Induced Myopathy
- Authors: Mikashinovich Z.I.1, Belousova E.S.2, Sarkisyan O.G.1
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Affiliations:
- Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation
- Department of Pharmaceutical Chemistry and Pharmacognosy, Rostov State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 162, No 4 (2017)
- Pages: 433-435
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238281
- DOI: https://doi.org/10.1007/s10517-017-3633-1
- ID: 238281
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Abstract
Administration of simvastatin was followed by a decrease in activities of superoxide dismutase and cytochrome oxidase in rat mitochondria, which attested to dysfunction of the respiratory chain. The decrease in total ATPase and Ca2+-ATPase activities in muscle tissue homogenates reflected impaired transport of active cations essential for muscle contraction. We conclude that abnormal relationships in the system of energy synthetic and energy-dependent processes in myocytes serve as the molecular basis for the formation of statin-induced degenerative changes.
About the authors
Z. I. Mikashinovich
Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation
Email: belousovalena@mail.ru
Russian Federation, Rostov-on-Don
E. S. Belousova
Department of Pharmaceutical Chemistry and Pharmacognosy, Rostov State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: belousovalena@mail.ru
Russian Federation, Rostov-on-Don
O. G. Sarkisyan
Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation
Email: belousovalena@mail.ru
Russian Federation, Rostov-on-Don
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