MRI Study for the Features of Brain Conduction Pathways in Patients with an Ultra-High Risk of Endogenous Psychoses
- Authors: Tomyshev A.S.1, Lebedeva I.S.1, Akhadov T.A.2, Omel’chenko M.A.1, Ublinskii M.V.2,3, Semenova N.A.2,3,4, Kaleda V.G.1
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Affiliations:
- Mental Health Research Center
- Emergency Children’s Surgery and Traumatology Research Institute
- N. M. Emanuel Institute of Biochemical Physics
- N. N. Semenov Institute of Chemical Physics
- Issue: Vol 162, No 4 (2017)
- Pages: 425-429
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238276
- DOI: https://doi.org/10.1007/s10517-017-3631-3
- ID: 238276
Cite item
Abstract
Diffusion parameters of brain tracts (n=18) were studied in 27 men with ultra-high risk of endogenous attack-like psychoses and 27 mentally healthy men of the same age group (fractional anisotropy; and average, radial, and axial diffusion). Correlation analysis was performed between these parameters and severity of mental disorders (SOPS scale). The indexes of radial diffusion and axial diffusion were shown to change in the left anterior thalamic radiation and right posterior cingulum bundle, respectively. Our results are consistent with published data that disturbances in the frontal and temporal lobes play an important role in the pathogenesis of schizophrenia. The degree of mental disorders correlated with diffusion parameters in the left and right anterior cingulum bundle.
About the authors
A. S. Tomyshev
Mental Health Research Center
Author for correspondence.
Email: alexander.tomyshev@gmail.com
Russian Federation, Moscow
I. S. Lebedeva
Mental Health Research Center
Email: alexander.tomyshev@gmail.com
Russian Federation, Moscow
T. A. Akhadov
Emergency Children’s Surgery and Traumatology Research Institute
Email: alexander.tomyshev@gmail.com
Russian Federation, Moscow
M. A. Omel’chenko
Mental Health Research Center
Email: alexander.tomyshev@gmail.com
Russian Federation, Moscow
M. V. Ublinskii
Emergency Children’s Surgery and Traumatology Research Institute; N. M. Emanuel Institute of Biochemical Physics
Email: alexander.tomyshev@gmail.com
Russian Federation, Moscow; Moscow
N. A. Semenova
Emergency Children’s Surgery and Traumatology Research Institute; N. M. Emanuel Institute of Biochemical Physics; N. N. Semenov Institute of Chemical Physics
Email: alexander.tomyshev@gmail.com
Russian Federation, Moscow; Moscow; Moscow
V. G. Kaleda
Mental Health Research Center
Email: alexander.tomyshev@gmail.com
Russian Federation, Moscow