Email this article Effects of Acyzol on Zinc Content in Rat Brain and Blood Plasma
- Authors: Yakimoskii A.F.1,2, Shantyr I.I.3, Vlasenko M.A.3,4, Yakovleva M.V.3
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Affiliations:
- Laboratory of Physiology and Pathology of Motor Behavior, I. P. Pavlov First St. Petersburg State Medical University
- Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology
- Department of Bioindicators, A. M. Nikiforov All-Russian Center of Emergency and Radiation, Ministry of Emergency Situations
- Department of Biophysics, St. Petersburg State University
- Issue: Vol 162, No 3 (2017)
- Pages: 293-294
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238140
- DOI: https://doi.org/10.1007/s10517-017-3597-1
- ID: 238140
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Abstract
Zinc level in the blood plasma and brain of rats was studied by inductively coupled plasma mass spectrometry. Maximum amount of zinc was observed in the cerebellum (15.0±5.5 μg/mg wet tissue). Single intraperitoneal administration of a zinc donor acyzol (24 mg/kg) did not change the content of this element in the tissues. Repeated injections of acyzol (7 injections over 14 days) significantly increased zinc level in rat plasma and brain. This elevation was most pronounced in the forebrain (cortex and subcortical structures). The rise in zinc concentration in blood plasma correlated with its level in the brain.
About the authors
A. F. Yakimoskii
Laboratory of Physiology and Pathology of Motor Behavior, I. P. Pavlov First St. Petersburg State Medical University; Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology
Author for correspondence.
Email: jakin2010@gmail.com
Russian Federation, St. Petersburg; St. Petersburg
I. I. Shantyr
Department of Bioindicators, A. M. Nikiforov All-Russian Center of Emergency and Radiation, Ministry of Emergency Situations
Email: jakin2010@gmail.com
Russian Federation, St. Petersburg
M. A. Vlasenko
Department of Bioindicators, A. M. Nikiforov All-Russian Center of Emergency and Radiation, Ministry of Emergency Situations; Department of Biophysics, St. Petersburg State University
Email: jakin2010@gmail.com
Russian Federation, St. Petersburg; St. Petersburg
M. V. Yakovleva
Department of Bioindicators, A. M. Nikiforov All-Russian Center of Emergency and Radiation, Ministry of Emergency Situations
Email: jakin2010@gmail.com
Russian Federation, St. Petersburg
