Email this article Modern Approaches to Studies of New Osteogenic Biomaterials on the Model of Regeneration of Critical-Size Cranial Defects in Rats
- Authors: Bartov M.S.1, Gromov A.V.1, Poponova M.S.1, Savina D.M.1, Nikitin K.E.1, Grunina T.M.1, Manskikh V.N.2, Gra O.A.1, Lunin V.G.1, Karyagina A.S.1,2, Gintsburg A.L.1
-
Affiliations:
- N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- Issue: Vol 162, No 2 (2016)
- Pages: 273-276
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238113
- DOI: https://doi.org/10.1007/s10517-016-3593-x
- ID: 238113
Cite item
Open Access
Access granted
Subscription Access
Abstract
Osteoinductive characteristics of new osteoplastic materials based on demineralized bone matrix of xenogenic origin with high and controlled degree of purification were studied on the model of regeneration of critical-size cranial defects in rats using modern approaches, including histological analysis, evaluation of morphological parameters of the bone tissue obtained by micro-computed tomography, and estimation of bone tissue growth rate using in vivo fluorochrome label. Demineralized bone matrix and, to a much greater extent, its activated form containing modified recombinant growth factor rhBMP-2 with high content of the dimeric form exhibited osteoinductive activity.
About the authors
M. S. Bartov
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: mike.bartov@gmail.com
Russian Federation, Moscow
A. V. Gromov
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
M. S. Poponova
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
D. M. Savina
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
K. E. Nikitin
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
T. M. Grunina
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
V. N. Manskikh
A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Email: mike.bartov@gmail.com
Russian Federation, Moscow
O. A. Gra
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
V. G. Lunin
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
A. S. Karyagina
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation; A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Email: mike.bartov@gmail.com
Russian Federation, Moscow; Moscow
A. L. Gintsburg
N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: mike.bartov@gmail.com
Russian Federation, Moscow
