Email this article Antimutagenic Effect of Afobazole on Blood Leukocytes in Individuals with Reproductive Dysfunction under Conditions of Anthropogenic Load
- Authors: Chshieva F.T.1
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Affiliations:
- Clinical Hospital of the North Ossetian Medical Academy
- Issue: Vol 162, No 2 (2016)
- Pages: 225-227
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238057
- DOI: https://doi.org/10.1007/s10517-016-3581-1
- ID: 238057
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Abstract
Increased frequency of cells with chromosomal aberrations was revealed in 48-h cultures of peripheral blood lymphocytes isolated North Ossetia residents with impaired reproductive function. After 2-week treatment with antimutagenic drug Afobazole, the percentage of cells with chromosomal aberrations significantly decreased from 3.77±0.20 to 2.48±0.24% (p<0.001). Significant differences between chromosome damage levels before and after administration of the drug suggest that Afobazole could be recommended for protective purposes to this group of patients.
About the authors
F. T. Chshieva
Clinical Hospital of the North Ossetian Medical Academy
Author for correspondence.
Email: fa-2009@yandex.ru
Russian Federation, Vladikavkaz, Republic of North Ossetia-Alania
