Effects of Single Administration of Bupropion on Carboxypeptidase E Activity in Structures of Rat Brain


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Abstract

Depression is associated with changes in the levels of some neurotransmitters in various brain structures. Being the key enzyme of peptide processing, carboxypeptidase E regulates their levels in various structures of the nervous system. Single injection of bupropion induced long-lasting changes in carboxypeptidase E activity in all brain structures. The decrease in enzyme activity observed in 12 and 24 h after bupropion injection confirmed the inhibiting effect of the drug on the hypothalamic–pituitary–adrenal axis. Activation of the enzyme in the medulla oblongata, hypothalamus, and hippocampus observed in 72 h after bupropion administration probably leads to enhanced synthesis and secretion of regulatory peptides (reduced during stress and depression) and stimulation of neurogenesis. Changes in enzyme activity can be a mechanism regulating the level of bioactive peptides involved in the pathogenesis of depression.

About the authors

A. D. Kruchinina

Department of General Biology and Biochemistry, Penza State University

Author for correspondence.
Email: a.d.kruchinina@mail.ru
Russian Federation, Penza

S. S. Gamzin

Department of General Biology and Biochemistry, Penza State University

Email: a.d.kruchinina@mail.ru
Russian Federation, Penza

M. T. Tengin

Department of General Biology and Biochemistry, Penza State University

Email: a.d.kruchinina@mail.ru
Russian Federation, Penza

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