Email this article Perinatal Brain Injury is Accompanied by Disturbances in Expression of SLC Protein Superfamily in Endotheliocytes of Hippocampal Microvessels
- Authors: Morgun A.V.1, Kuvacheva N.V.1, Khilazheva E.D.1, Pozhilenkova E.A.1, Gorina Y.V.1, Malinovskaya N.A.1, Komleva Y.K.1, Lopatina O.L.1, Panina Y.A.1, Gasymly E.D.1, Salmina A.B.1
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Affiliations:
- Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
- Issue: Vol 161, No 6 (2016)
- Pages: 770-774
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/237763
- DOI: https://doi.org/10.1007/s10517-016-3506-z
- ID: 237763
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Abstract
The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.
About the authors
A. V. Morgun
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Author for correspondence.
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
N. V. Kuvacheva
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
E. D. Khilazheva
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
E. A. Pozhilenkova
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
Ya. V. Gorina
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
N. A. Malinovskaya
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
Yu. K. Komleva
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
O. L. Lopatina
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
Yu. A. Panina
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
E. D. Gasymly
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
A. B. Salmina
Research Institute of Molecular Medicine and Pathobiochemistry, V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Email: 441682@mail.ru
Russian Federation, Krasnoyarsk
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